3L1B

Complex Structure of FXR Ligand-binding domain with a tetrahydroazepinoindole compound

3L1B の概要

• エントリーDOI: 10.2210/pdb3l1b/pdb
• 関連するPDBエントリー: 1OSH
• 分子名称: Farnesoid X receptor, 1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morpholin-4-ylpropoxy)phenyl]carbonyl}-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate (3 entities in total)
• 機能のキーワード: nuclear receptor, fxr agonist, fxr ligand-binding domain, nucleus, receptor, transcription regulation, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27705.78

構造登録者

Xu, W.,Lundquist, J.T. (登録日: 2009-12-11, 公開日: 2010-03-02, 最終更新日: 2024-04-03)

• 主引用文献: Lundquist, J.T.,Harnish, D.C.,Kim, C.Y.,Mehlmann, J.F.,Unwalla, R.J.,Phipps, K.M.,Crawley, M.L.,Commons, T.,Green, D.M.,Xu, W.,Hum, W.T.,Eta, J.E.,Feingold, I.,Patel, V.,Evans, M.J.,Lai, K.,Borges-Marcucci, L.,Mahaney, P.E.,Wrobel, J.E.; Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates.; J.Med.Chem., 53:1774-1787, 2010; PubMed: 20095622; DOI: 10.1021/jm901650u

実験手法

X-RAY DIFFRACTION (1.9 Å)