3L1B
Complex Structure of FXR Ligand-binding domain with a tetrahydroazepinoindole compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Farnesoid X receptor | polymer | 233 | 27142.1 | 1 | UniProt (B7ZM06) Pfam (PF00104) UniProt (by SIFTS) (Q96RI1) In PDB | Homo sapiens (human) | NR1H4 protein |
| 2 | A | 1-methylethyl 8-fluoro-1,1-dimethyl-3-{[4-(3-morpholin-4-ylpropoxy)phenyl]carbonyl}-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate | non-polymer | 563.7 | 1 | Chemie (635) | |||
| 3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 248 - 476 (UniProt: B7ZM06)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | expression tag |
| Ser 245 | - | expression tag |
| His 246 | - | expression tag |
| Gly 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27142.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 563.7 | |
| All* | Total formula weight | 27705.8 |
