3L1B

Complex Structure of FXR Ligand-binding domain with a tetrahydroazepinoindole compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 635 A 1

Chain	Residue
A	PHE288
A	LEU352
A	ILE356
A	TYR373
A	TRP458
A	TRP473
A	LEU291
A	THR292
A	MET294
A	ALA295
A	MET332
A	SER336
A	ILE339
A	LYS343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	PRO345
A	SER375
A	GLN383
A	ASN461

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	MET456

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LEU289

---