3KXU

Crystal structure of human ferritin FTL498InsTC pathogenic mutant

Summary for 3KXU

Entry DOI	10.2210/pdb3kxu/pdb
Descriptor	Ferritin, CADMIUM ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	iron storage protein, disorder, iron, metal binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22770.08
Authors	Granier, T.,Gallois, B.,Langlois d'Estaintot, B.,Arosio, P. (deposition date: 2009-12-04, release date: 2010-02-09, Last modification date: 2023-11-01)
Primary citation	Luscieti, S.,Santambrogio, P.,Langlois d'Estaintot, B.,Granier, T.,Cozzi, A.,Poli, M.,Gallois, B.,Finazzi, D.,Cattaneo, A.,Levi, S.,Arosio, P. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J.Biol.Chem., 285:11948-11957, 2010 Cited by PubMed: 20159981 DOI: 10.1074/jbc.M109.096404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation