3KWZ
Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor
Summary for 3KWZ
Entry DOI | 10.2210/pdb3kwz/pdb |
Related | 3KX1 |
Descriptor | Cathepsin K, SULFATE ION, 4-(3-piperidin-1-ylpropyl)-6-[3-(trifluoromethyl)phenyl]pyrimidine-2-carbonitrile, ... (4 entities in total) |
Functional Keywords | cathepsin k, enzyme inhibitor, covalent reversible inhibitor, disease mutation, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24474.26 |
Authors | Fradera, X.,Uitdehaag, J.C.M.,van Zeeland, M. (deposition date: 2009-12-02, release date: 2010-03-02, Last modification date: 2024-04-03) |
Primary citation | Rankovic, Z.,Cai, J.,Kerr, J.,Fradera, X.,Robinson, J.,Mistry, A.,Hamilton, E.,McGarry, G.,Andrews, F.,Caulfield, W.,Cumming, I.,Dempster, M.,Waller, J.,Scullion, P.,Martin, I.,Mitchell, A.,Long, C.,Baugh, M.,Westwood, P.,Kinghorn, E.,Bruin, J.,Hamilton, W.,Uitdehaag, J.,van Zeeland, M.,Potin, D.,Saniere, L.,Fouquet, A.,Chevallier, F.,Deronzier, H.,Dorleans, C.,Nicolai, E. Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors Bioorg.Med.Chem.Lett., 20:1524-1527, 2010 Cited by PubMed: 20149657DOI: 10.1016/j.bmcl.2010.01.100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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