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3KWZ

Cathepsin K in complex with a non-selective 2-cyano-pyrimidine inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 216
ChainResidue
AGLN19
AARG127
AHIS162
ATRP184
AKWZ222
AHOH244
AHOH277

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 217
ChainResidue
AGLY185
AGLU186
AASN187
ALYS214
AHOH337
AASN18
AARG111

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 218
ChainResidue
APRO2
AASP3
ALEU139
ATHR140
ASER141

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 219
ChainResidue
ALYS10
APHE144
ATYR145
ASER146
ALYS147
AHOH275
AHOH286

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 220
ChainResidue
AGLN92
AGLU93
ALYS173
AHOH271
AHOH316
AHOH354

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 221
ChainResidue
AASN117
ALYS119
AARG123
AHOH260
AHOH320
AHOH375

site_idAC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE KWZ A 222
ChainResidue
AGLN19
AGLY23
ACYS25
AGLY64
AGLY65
AGLY66
ATYR67
AMET68
AALA134
ALEU160
AASN161
AHIS162
AALA163
ALEU209
ASO4216

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ACYS25
AHIS162
AASN182

218500

PDB entries from 2024-04-17

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