3KWW

Crystal structure of the 'restriction triad' mutant of HLA B*3508, beta-2-microglobulin and EBV peptide

3KWW の概要

• エントリーDOI: 10.2210/pdb3kww/pdb
• 関連するPDBエントリー: 3KXF
• 分子名称: HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, peptide from Trans-activator protein BZLF1, ... (7 entities in total)
• 機能のキーワード: mhc-peptide, hla, disulfide bond, immune response, membrane, mhc i, polymorphism, immunoglobulin domain, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P30685; Secreted . Note=(Microbial infection) In the presence of M: P61769; Host nucleus : P03206
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 46376.34

構造登録者

Archbold, J.K.,Tynan, F.E.,Gras, S.,Rossjohn, J. (登録日: 2009-12-01, 公開日: 2010-06-09, 最終更新日: 2023-11-01)

• 主引用文献: Burrows, S.R.,Chen, Z.,Archbold, J.K.,Tynan, F.E.,Beddoe, T.,Kjer-Nielsen, L.,Miles, J.J.,Khanna, R.,Moss, D.J.,Liu, Y.C.,Gras, S.,Kostenko, L.,Brennan, R.M.,Clements, C.S.,Brooks, A.G.,Purcell, A.W.,McCluskey, J.,Rossjohn, J.; Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability; Proc.Natl.Acad.Sci.USA, 2010; PubMed: 20483993; DOI: 10.1073/pnas.1004926107

実験手法

X-RAY DIFFRACTION (2.18 Å)