3KWB
Structure of CatK covalently bound to a dioxo-triazine inhibitor
Summary for 3KWB
Entry DOI | 10.2210/pdb3kwb/pdb |
Related | 3KW9 |
Descriptor | Cathepsin K, 3,5-dioxo-4-(3-piperidin-1-ylpropyl)-2-[3-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (3 entities in total) |
Functional Keywords | covalent bond, cys 25, thioimidate, disease mutation, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 2 |
Total formula weight | 47861.74 |
Authors | Uitdehaag, J.C.M.,van Zeeland, M. (deposition date: 2009-12-01, release date: 2010-04-07, Last modification date: 2011-07-13) |
Primary citation | Rankovic, Z.,Cai, J.,Fradera, X.,Dempster, M.,Mistry, A.,Mitchell, A.,Long, C.,Hamilton, E.,King, A.,Boucharens, S.,Jamieson, C.,Gillespie, J.,Cumming, I.,Uitdehaag, J.,van Zeeland, M. Dioxo-triazines as a novel series of cathepsin K inhibitors Bioorg.Med.Chem.Lett., 20:1488-1490, 2010 Cited by PubMed: 20153187DOI: 10.1016/j.bmcl.2010.01.116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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