3KW5

Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester

Summary for 3KW5

Entry DOI	10.2210/pdb3kw5/pdb
Related	2ETL 3KVF
Descriptor	Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin, METHYL 4-AMINOBUTANOATE (3 entities in total)
Functional Keywords	enzyme-suicide substrate complex, hydrolase, ligase, protease, thiol protease, ubl conjugation pathway, isopeptide bond, ubl conjugation, hydrolase-hydrolase inhibitor complex, acetylation, cytoplasm, disease mutation, glycoprotein, oxidation, polymorphism, nucleus, phosphoprotein, hydrolase-signaling protein complex, hydrolase/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P09936
Total number of polymer chains	2
Total formula weight	33903.72
Authors	Maiti, T.K.,Boudreaux, D.A.,Das, C. (deposition date: 2009-11-30, release date: 2010-06-16, Last modification date: 2023-11-15)
Primary citation	Boudreaux, D.A.,Maiti, T.K.,Davies, C.W.,Das, C. Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc.Natl.Acad.Sci.USA, 107:9117-9122, 2010 Cited by PubMed: 20439756 DOI: 10.1073/pnas.0910870107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation