3KVF

Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester

Summary for 3KVF

• Entry DOI: 10.2210/pdb3kvf/pdb
• Related: 2ETL 3KW5
• Descriptor: Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin, METHYL 4-AMINOBUTANOATE, ... (4 entities in total)
• Functional Keywords: enzyme-suicide substrate complex, cytoplasm, disease mutation, glycoprotein, hydrolase, ligase, oxidation, polymorphism, protease, thiol protease, ubl conjugation pathway, isopeptide bond, nucleus, phosphoprotein, ubl conjugation, hydrolase-hydrolase inhibitor complex, acetylation, hydrolase-signaling protein complex, hydrolase/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P09936
• Total number of polymer chains: 2
• Total formula weight: 33921.76

Authors

Davies, C.W.,Maiti, T.K.,Das, C. (deposition date: 2009-11-30, release date: 2010-06-16, Last modification date: 2023-11-15)

• Primary citation: Boudreaux, D.A.,Maiti, T.K.,Davies, C.W.,Das, C.; Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation.; Proc.Natl.Acad.Sci.USA, 107:9117-9122, 2010; PubMed: 20439756; DOI: 10.1073/pnas.0910870107

Experimental method

X-RAY DIFFRACTION (2.8 Å)