3KTM

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

Summary for 3KTM

• Entry DOI: 10.2210/pdb3ktm/pdb
• Descriptor: Amyloid beta A4 protein, (3R)-butane-1,3-diol, SULFATE ION, ... (5 entities in total)
• Functional Keywords: protein structure, alzheimer disease, amyloid, amyloidosis, apoptosis, cell adhesion, copper, disease mutation, disulfide bond, endocytosis, heparin-binding, metal-binding, neurodegeneration, notch signaling pathway, proteoglycan, zinc, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 8
• Total formula weight: 175534.10

Authors

Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E. (deposition date: 2009-11-25, release date: 2010-02-23, Last modification date: 2023-09-06)

• Primary citation: Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E.; Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.; Proc.Natl.Acad.Sci.USA, 107:5381-5386, 2010; PubMed: 20212142; DOI: 10.1073/pnas.0911326107

Experimental method

X-RAY DIFFRACTION (2.7 Å)