3KTM
Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)
Summary for 3KTM
Entry DOI | 10.2210/pdb3ktm/pdb |
Descriptor | Amyloid beta A4 protein, (3R)-butane-1,3-diol, SULFATE ION, ... (5 entities in total) |
Functional Keywords | protein structure, alzheimer disease, amyloid, amyloidosis, apoptosis, cell adhesion, copper, disease mutation, disulfide bond, endocytosis, heparin-binding, metal-binding, neurodegeneration, notch signaling pathway, proteoglycan, zinc, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 8 |
Total formula weight | 175534.10 |
Authors | Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E. (deposition date: 2009-11-25, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E. Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc.Natl.Acad.Sci.USA, 107:5381-5386, 2010 Cited by PubMed: 20212142DOI: 10.1073/pnas.0911326107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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