3KTM

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

3KTM の概要

• エントリーDOI: 10.2210/pdb3ktm/pdb
• 分子名称: Amyloid beta A4 protein, (3R)-butane-1,3-diol, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein structure, alzheimer disease, amyloid, amyloidosis, apoptosis, cell adhesion, copper, disease mutation, disulfide bond, endocytosis, heparin-binding, metal-binding, neurodegeneration, notch signaling pathway, proteoglycan, zinc, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 175534.10

構造登録者

Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E. (登録日: 2009-11-25, 公開日: 2010-02-23, 最終更新日: 2023-09-06)

• 主引用文献: Dahms, S.O.,Hoefgen, S.,Roeser, D.,Schlott, B.,Guhrs, K.H.,Than, M.E.; Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.; Proc.Natl.Acad.Sci.USA, 107:5381-5386, 2010; PubMed: 20212142; DOI: 10.1073/pnas.0911326107

実験手法

X-RAY DIFFRACTION (2.7 Å)