3KRK

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2

3KRK の概要

• エントリーDOI: 10.2210/pdb3krk/pdb
• 関連するPDBエントリー: 1CVU 1DIY 3HS5 3HS6 3HS7
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: cox-2, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, oxidoreductase, peroxidase, phosphoprotein, prostaglandin biosynthesis
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141234.33

構造登録者

Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. (登録日: 2009-11-18, 公開日: 2010-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G.; Structural basis of fatty acid substrate binding to cyclooxygenase-2.; J.Biol.Chem., 285:22152-22163, 2010; PubMed: 20463020; DOI: 10.1074/jbc.M110.119867

実験手法

X-RAY DIFFRACTION (2.4 Å)