3KRK
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2
3KRK の概要
エントリーDOI | 10.2210/pdb3krk/pdb |
関連するPDBエントリー | 1CVU 1DIY 3HS5 3HS6 3HS7 |
分子名称 | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
機能のキーワード | cox-2, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, oxidoreductase, peroxidase, phosphoprotein, prostaglandin biosynthesis |
由来する生物種 | Mus musculus (mouse) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 141234.33 |
構造登録者 | |
主引用文献 | Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J.Biol.Chem., 285:22152-22163, 2010 Cited by PubMed: 20463020DOI: 10.1074/jbc.M110.119867 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
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