3KR6

MurA dead-end complex with fosfomycin

3KR6 の概要

• エントリーDOI: 10.2210/pdb3kr6/pdb
• 関連するPDBエントリー: 3KQA 3KQJ
• 分子名称: UDP-N-acetylglucosamine 1-carboxyvinyltransferase, [(1R)-1-hydroxypropyl]phosphonic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (4 entities in total)
• 機能のキーワード: closed enzyme state, inside-out alpha/beta barrel, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm (Probable): P0A749
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45619.95

構造登録者

Schonbrunn, E. (登録日: 2009-11-17, 公開日: 2010-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E.; The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .; Biochemistry, 49:4276-4282, 2010; PubMed: 20392080; DOI: 10.1021/bi100365b

実験手法