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3KQN

Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism

3KQN の概要
エントリーDOI10.2210/pdb3kqn/pdb
関連するPDBエントリー3KQH 3KQK 3KQL 3KQU
分子名称Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3', BERYLLIUM TRIFLUORIDE ION, ... (6 entities in total)
機能のキーワードhelicase-substrate transition-state complex, hcv, ns3 protein, helicase, dna-binding, hydrolase-dna complex, hydrolase/dna
由来する生物種Hepatitis C virus (HCV)
細胞内の位置Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q9WMX2
タンパク質・核酸の鎖数2
化学式量合計49070.40
構造登録者
Gu, M.,Rice, C.M. (登録日: 2009-11-17, 公開日: 2010-01-26, 最終更新日: 2024-02-21)
主引用文献Gu, M.,Rice, C.M.
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Proc.Natl.Acad.Sci.USA, 107:521-528, 2010
Cited by
PubMed: 20080715
DOI: 10.1073/pnas.0913380107
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.05 Å)
構造検証レポート
Validation report summary of 3kqn
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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