3KQL
Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism
3KQL の概要
エントリーDOI | 10.2210/pdb3kql/pdb |
関連するPDBエントリー | 3KQH 3KQK 3KQN 3KQU |
分子名称 | Serine protease/NTPase/helicase NS3, 5'-D(*TP*TP*TP*TP*TP*T)-3', TETRAFLUOROALUMINATE ION, ... (6 entities in total) |
機能のキーワード | helicase-substrate transition-state complex, hcv, ns3 protein, helicase, dna-binding, hydrolase-dna complex, hydrolase/dna |
由来する生物種 | Hepatitis C virus (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q9WMX2 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 98153.48 |
構造登録者 | |
主引用文献 | Gu, M.,Rice, C.M. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc.Natl.Acad.Sci.USA, 107:521-528, 2010 Cited by PubMed: 20080715DOI: 10.1073/pnas.0913380107 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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