3KQL
Three Conformational Snapshots of the Hepatitis C Virus NS3 Helicase Reveal a Ratchet Translocation Mechanism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine protease/NTPase/helicase NS3 | polymer | 437 | 46742.1 | 2 | UniProt (Q9WMX2) Pfam (PF07652) Pfam (PF22027) | Hepatitis C virus (HCV) | Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease/NTPase/helicase NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68 |
| 2 | C, D (E, F) | 5'-D(*TP*TP*TP*TP*TP*T)-3' | polymer | 6 | 1780.2 | 2 | |||
| 3 | E, H (A, B) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
| 4 | F, I (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | G, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, L, M, N (A, B, E, F) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A, B: 189 - 624 (UniProt: Q9WMX2)
| PDB | External Database | Details |
|---|---|---|
| Ala 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97044.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1109.0 | |
| All* | Total formula weight | 98153.5 |
