3KMZ

Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment

3KMZ の概要

• エントリーDOI: 10.2210/pdb3kmz/pdb
• 分子名称: Retinoic acid receptor alpha, Nuclear receptor corepressor 1, 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid, ... (5 entities in total)
• 機能のキーワード: nuclear receptor transcription factor ligand binding domain, dna-binding, metal-binding, nucleus, phosphoprotein, proto-oncogene, receptor, transcription, transcription regulation, zinc-finger, chromatin regulator, repressor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P10276; Nucleus (By similarity): O75376
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66066.24

構造登録者

Bourguet, W.,le Maire, A. (登録日: 2009-11-11, 公開日: 2010-06-02, 最終更新日: 2023-11-22)

• 主引用文献: le Maire, A.,Teyssier, C.,Erb, C.,Grimaldi, M.,Alvarez, S.,de Lera, A.R.,Balaguer, P.,Gronemeyer, H.,Royer, C.A.,Germain, P.,Bourguet, W.; A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.; Nat.Struct.Mol.Biol., 17:801-807, 2010; PubMed: 20543827; DOI: 10.1038/nsmb.1855

実験手法

X-RAY DIFFRACTION (2.1 Å)