3KME
Crystal structure of catalytic domain of TACE with phenyl-pyrrolidinyl-tartrate inhibitor
3KME の概要
エントリーDOI | 10.2210/pdb3kme/pdb |
関連するPDBエントリー | 1bkc 2fv9 3ewj 3KMC |
関連するBIRD辞書のPRD_ID | PRD_000919 |
分子名称 | TNF-alpha-converting enzyme, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (6 entities in total) |
機能のキーワード | a disintegrin and metalloproteinase domain 17, tnf-alpha-converting enzyme, tnf-alpha convertase, snake venom-like protease, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, zymogen, hydrolase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P78536 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 62119.16 |
構造登録者 | |
主引用文献 | Rosner, K.E.,Guo, Z.,Orth, P.,Shipps, G.W.,Belanger, D.B.,Chan, T.Y.,Curran, P.J.,Dai, C.,Deng, Y.,Girijavallabhan, V.M.,Hong, L.,Lavey, B.J.,Lee, J.F.,Li, D.,Liu, Z.,Popovici-Muller, J.,Ting, P.C.,Vaccaro, H.,Wang, L.,Wang, T.,Yu, W.,Zhou, G.,Niu, X.,Sun, J.,Kozlowski, J.A.,Lundell, D.J.,Madison, V.,McKittrick, B.,Piwinski, J.J.,Shih, N.Y.,Arshad Siddiqui, M.,Strickland, C.O. The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg.Med.Chem.Lett., 20:1189-1193, 2009 Cited by PubMed: 20022498DOI: 10.1016/j.bmcl.2009.12.004 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.85 Å) |
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