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3KME

Crystal structure of catalytic domain of TACE with phenyl-pyrrolidinyl-tartrate inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 1
ChainResidue
AHIS405
AHIS409
AHIS415
AINN485
AHOH492

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE INN A 485
ChainResidue
ASER330
AMET345
AGLY346
ATHR347
ALEU348
AGLY349
AASN389
ATYR390
AHIS405
AGLU406
AHIS409
AHIS415
ATYR436
APRO437
AILE438
AALA439
AHOH490
AHOH491
AHOH492
BARG357
AZN1
AHOH80
AHOH167
AGLU327

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE IPA A 7
ChainResidue
ALEU285
ALYS286
ASER287
APRO288
AASN299

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 2
ChainResidue
BHIS405
BHIS409
BHIS415
BZ59485

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE Z59 B 485
ChainResidue
BZN2
BLEU348
BGLY349
BHIS405
BGLU406
BHIS409
BHIS415
BVAL434
BTYR436
BPRO437
BILE438
BALA439
BHOH543
BHOH546

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VTTHELGHNF
ChainResidueDetails
AVAL402-PHE411

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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