3KM9

Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7

3KM9 の概要

• エントリーDOI: 10.2210/pdb3km9/pdb
• 関連するPDBエントリー: 2QEJ 3CU7 3KLS
• 分子名称: Complement C5, Staphylococcal enterotoxin-like toxin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: ob-fold, beta-grasp domain, fn3 domain, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, disulfide bond, glycoprotein, immune response, inflammatory response, innate immunity, membrane attack complex, secreted, immune system
• 由来する生物種: Staphylococcus aureus subsp. aureus; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 402446.22

構造登録者

Laursen, N.S.,Gordon, N.,Hermans, S.,Lorenz, N.,Jackson, N.,Wines, B.,Spillner, E.,Christensen, J.B.,Jensen, M.,Fredslund, F.,Bjerre, M.,Sottrup-Jensen, L.,Fraser, J.D.,Andersen, G.R. (登録日: 2009-11-10, 公開日: 2009-12-01, 最終更新日: 2023-11-01)

• 主引用文献: Laursen, N.S.,Gordon, N.,Hermans, S.,Lorenz, N.,Jackson, N.,Wines, B.,Spillner, E.,Christensen, J.B.,Jensen, M.,Fredslund, F.,Bjerre, M.,Sottrup-Jensen, L.,Fraser, J.D.,Andersen, G.R.; Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus; Proc.Natl.Acad.Sci.USA, 107:3681-3686, 2010; PubMed: 20133685; DOI: 10.1073/pnas.0910565107

実験手法

X-RAY DIFFRACTION (4.2 Å)