3KLM
17beta-HSD1 in complex with DHT
Summary for 3KLM
Entry DOI | 10.2210/pdb3klm/pdb |
Descriptor | Estradiol 17-beta-dehydrogenase 1, 5-ALPHA-DIHYDROTESTOSTERONE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | dht, lipid synthesis, steroid biosynthesis, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14061 |
Total number of polymer chains | 1 |
Total formula weight | 35356.48 |
Authors | Mazumdar, M. (deposition date: 2009-11-08, release date: 2010-04-21, Last modification date: 2024-02-21) |
Primary citation | Aka, J.A.,Mazumdar, M.,Chen, C.Q.,Poirier, D.,Lin, S.X. 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production. Mol.Endocrinol., 24:832-845, 2010 Cited by PubMed: 20172961DOI: 10.1210/me.2009-0468 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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