3KLM
17beta-HSD1 in complex with DHT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| X | 0005496 | molecular_function | steroid binding |
| X | 0005515 | molecular_function | protein binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005829 | cellular_component | cytosol |
| X | 0006629 | biological_process | lipid metabolic process |
| X | 0006694 | biological_process | steroid biosynthetic process |
| X | 0006703 | biological_process | estrogen biosynthetic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0036094 | molecular_function | small molecule binding |
| X | 0042803 | molecular_function | protein homodimerization activity |
| X | 0047035 | molecular_function | testosterone dehydrogenase (NAD+) activity |
| X | 0047045 | molecular_function | testosterone dehydrogenase (NADP+) activity |
| X | 0050661 | molecular_function | NADP binding |
| X | 0060348 | biological_process | bone development |
| X | 0061370 | biological_process | testosterone biosynthetic process |
| X | 0070401 | molecular_function | NADP+ binding |
| X | 0071248 | biological_process | cellular response to metal ion |
| X | 0072582 | molecular_function | 17-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| X | 1903924 | molecular_function | estradiol binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DHT X 732 |
| Chain | Residue |
| X | VAL143 |
| X | LEU149 |
| X | PRO187 |
| X | TYR218 |
| X | HIS221 |
| X | SER222 |
| X | VAL225 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL X 328 |
| Chain | Residue |
| X | VAL84 |
| X | PHE125 |
| X | ASP128 |
| X | ARG76 |
| X | ARG83 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA |
| Chain | Residue | Details |
| X | SER142-ALA170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8805577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"8994190","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
