3KLA

Ca2+ release from the endoplasmic reticulum of NY-ESO-1 specific T cells is modulated by the affinity of T cell receptor and by the use of the CD8 co-receptor

Summary for 3KLA

• Entry DOI: 10.2210/pdb3kla/pdb
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NYESO-1 peptide analogue, ... (4 entities in total)
• Functional Keywords: mhc, tumour, immunology, disulfide bond, glycoprotein, immune response, membrane, mhc i, transmembrane, immunoglobulin domain, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Cytoplasm: P78358
• Total number of polymer chains: 6
• Total formula weight: 89675.84

Authors

Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L. (deposition date: 2009-11-07, release date: 2010-02-16, Last modification date: 2021-10-13)

• Primary citation: Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L.,Hutchinson, S.L.,Sewell, A.K.,Griffiths, G.M.,van der Merwe, P.A.,Jones, E.Y.,Galione, A.,Cerundolo, V.; Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1-Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor.; J.Immunol., 184:1829-1839, 2010; PubMed: 20053942; DOI: 10.4049/jimmunol.0902103

Experimental method

X-RAY DIFFRACTION (1.65 Å)