Ca2+ release from the endoplasmic reticulum of NY-ESO-1 specific T cells is modulated by the affinity of T cell receptor and by the use of the CD8 co-receptor

Summary for 3KLA

DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NYESO-1 peptide analogue, ... (4 entities in total)
Functional Keywordsmhc, tumour, immunology, disulfide bond, glycoprotein, immune response, membrane, mhc i, transmembrane, immunoglobulin domain, immune system
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted P61769
Cytoplasm P78358
Total number of polymer chains6
Total molecular weight89675.84
Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L. (deposition date: 2009-11-07, release date: 2010-02-16, Last modification date: 2011-07-13)
Primary citation
Chen, J.L.,Morgan, A.J.,Stewart-Jones, G.,Shepherd, D.,Bossi, G.,Wooldridge, L.,Hutchinson, S.L.,Sewell, A.K.,Griffiths, G.M.,van der Merwe, P.A.,Jones, E.Y.,Galione, A.,Cerundolo, V.
Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1-Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor.
J.Immunol., 184:1829-1839, 2010
PubMed: 20053942 (PDB entries with the same primary citation)
DOI: 10.4049/jimmunol.0902103
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236120.5%1.9%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report