3KLA
Ca2+ release from the endoplasmic reticulum of NY-ESO-1 specific T cells is modulated by the affinity of T cell receptor and by the use of the CD8 co-receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 275 | 31854.2 | 2 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) In PDB | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B, E | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | C, F | NYESO-1 peptide analogue | polymer | 9 | 1104.4 | 2 | UniProt (P78358) In PDB | Homo sapiens | |
| 4 | water | water | 18.0 | 1703 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 99 (UniProt: P61769)
C, F: 1 - 9 (UniProt: P78358)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 9 | Cys 165 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89675.8 | |
| All* | Total formula weight | 89675.8 |
