3KLA

Ca2+ release from the endoplasmic reticulum of NY-ESO-1 specific T cells is modulated by the affinity of T cell receptor and by the use of the CD8 co-receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	HLA class I histocompatibility antigen, A-2 alpha chain	polymer	275	31854.2	2	UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439)	Homo sapiens (human)	MHC class I antigen A*2
2	B, E (B, E)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)	Beta-2-microglobulin form pI 5.3
3	C, F (C, F)	NYESO-1 peptide analogue	polymer	9	1104.4	2	UniProt (P78358)	Homo sapiens
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	1703	Chemie (HOH)

Sequence modifications

B, E: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C, F: 1 - 9 (UniProt: P78358)

PDB	External Database	Details
Leu 9	Cys 165	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	89675.8
All*	Total formula weight	89675.8

*Water molecules are not included.