3KKT

Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.

Summary for 3KKT

• Entry DOI: 10.2210/pdb3kkt/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 5-{3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl}tetrahydropyrimidin-2(1H)-one, ... (6 entities in total)
• Functional Keywords: phosphodiesterase, alternative splicing, hydrolase, phosphoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 92404.97

Authors

Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M. (deposition date: 2009-11-06, release date: 2009-11-24, Last modification date: 2023-09-06)

• Primary citation: Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M.; Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.; To be Published,

Experimental method

X-RAY DIFFRACTION (2.48 Å)