3KKT
Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.
Summary for 3KKT
Entry DOI | 10.2210/pdb3kkt/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, 5-{3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl}tetrahydropyrimidin-2(1H)-one, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, alternative splicing, hydrolase, phosphoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 92404.97 |
Authors | Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M. (deposition date: 2009-11-06, release date: 2009-11-24, Last modification date: 2023-09-06) |
Primary citation | Cheng, R.K.Y.,Crawley, L.,Barker, J.,Whittaker, M. Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509. To be Published, |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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