3KFS

HIV Protease (PR) dimer with inhibitor TL-3 bound and fragment 2F4 in the outside/top of flap

3KFS の概要

• エントリーDOI: 10.2210/pdb3kfs/pdb
• 関連するPDBエントリー: 2AZ8 3KF0 3KF1 3KFN 3KFP 3KFR
• 関連するBIRD辞書のPRD_ID: PRD_000434
• 分子名称: Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: hiv-1, protease, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23155.64

構造登録者

Stout, C.D. (登録日: 2009-10-28, 公開日: 2010-02-23, 最終更新日: 2023-09-06)

• 主引用文献: Perryman, A.L.,Zhang, Q.,Soutter, H.H.,Rosenfeld, R.,McRee, D.E.,Olson, A.J.,Elder, J.E.,David Stout, C.; Fragment-based screen against HIV protease.; Chem.Biol.Drug Des., 75:257-268, 2010; PubMed: 20659109; DOI: 10.1111/j.1747-0285.2009.00943.x

実験手法

X-RAY DIFFRACTION (1.8 Å)