3KFN
HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking
Summary for 3KFN
Entry DOI | 10.2210/pdb3kfn/pdb |
Related | 2AZ8 3KF0 3KF1 3KFP 3KFR 3KFS |
Related PRD ID | PRD_000434 |
Descriptor | Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, (1S,2S)-2-methylcyclohexanol, ... (7 entities in total) |
Functional Keywords | hiv-1, protease, exo site, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 23155.79 |
Authors | Stout, C.D. (deposition date: 2009-10-27, release date: 2010-02-23, Last modification date: 2023-09-06) |
Primary citation | Perryman, A.L.,Zhang, Q.,Soutter, H.H.,Rosenfeld, R.,McRee, D.E.,Olson, A.J.,Elder, J.E.,David Stout, C. Fragment-based screen against HIV protease. Chem.Biol.Drug Des., 75:257-268, 2010 Cited by PubMed: 20659109DOI: 10.1111/j.1747-0285.2009.00943.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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