3KEH

Crystal Structure of N370S Glucocerebrosidase mutant at pH 7.4

Summary for 3KEH

• Entry DOI: 10.2210/pdb3keh/pdb
• Related: 3KE0
• Descriptor: Glucocerebrosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: glucocerebrosidase, acid-beta-glucosidase, n370s, glucosyceremidase, tim barrel, alternative initiation, disease mutation, disulfide bond, gaucher disease, glycoprotein, glycosidase, hydrolase, ichthyosis, lipid metabolism, lysosome, membrane, sphingolipid metabolism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 113305.11

Authors

Wei, R.R.,Boucher, S.,Pan, C.Q.,Edmunds, T. (deposition date: 2009-10-26, release date: 2010-10-27, Last modification date: 2024-11-06)

• Primary citation: Wei, R.R.,Boucher, S.,Hughes, H.,Guziewica, N.,Vanpatten, S.,Pan, C.Q.,Edmunds, T.; Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy; To be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)