3K8O

Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH

Summary for 3K8O

• Entry DOI: 10.2210/pdb3k8o/pdb
• Related: 1RR6 1RSZ 3K8Q
• Descriptor: Purine nucleoside phosphorylase, SULFATE ION, 7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE, ... (4 entities in total)
• Functional Keywords: transition state analog inhibitor, datme-immh, hpnp, pnp, purine nucleoside phosphorylase, cytoskeleton, disease mutation, glycosyltransferase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton : P00491
• Total number of polymer chains: 6
• Total formula weight: 196255.88

Authors

Ho, M.,Rinaldo-matthis, A.,Almo, S.C.,Schramm, V.L. (deposition date: 2009-10-14, release date: 2010-03-02, Last modification date: 2024-02-21)

• Primary citation: Ho, M.,Rinaldo-matthis, A.,Almo, S.C.,Schramm, V.L.; Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H; Proc.Natl.Acad.Sci.USA, 2010

Experimental method

X-RAY DIFFRACTION (2.4 Å)