3JYJ
Structure-Based Design of Novel PIN1 Inhibitors (II)
Summary for 3JYJ
Entry DOI | 10.2210/pdb3jyj/pdb |
Related | 3I6C 3IK8 3IKD 3IKG |
Descriptor | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, (2R,4E)-2-[(naphthalen-2-ylcarbonyl)amino]-5-phenylpent-4-enoic acid (3 entities in total) |
Functional Keywords | sbdd, small molecule, ppiase, cell cycle, isomerase, nucleus, phosphoprotein, rotamase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q13526 |
Total number of polymer chains | 2 |
Total formula weight | 28015.18 |
Authors | Greasley, S.E.,Ferre, R.A. (deposition date: 2009-09-21, release date: 2010-04-07, Last modification date: 2024-04-03) |
Primary citation | Dong, L.,Marakovits, J.,Hou, X.,Guo, C.,Greasley, S.,Dagostino, E.,Ferre, R.,Johnson, M.C.,Kraynov, E.,Thomson, J.,Pathak, V.,Murray, B.W. Structure-based design of novel human Pin1 inhibitors (II). Bioorg.Med.Chem.Lett., 20:2210-2214, 2010 Cited by PubMed: 20207139DOI: 10.1016/j.bmcl.2010.02.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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