3JVG

Crystal Structure of chicken CD1-1

3JVG の概要

• エントリーDOI: 10.2210/pdb3jvg/pdb
• 関連するPDBエントリー: 1ONQ 1UQS 1ZT4 2FIK 3dbx
• 分子名称: T-cell surface glycoprotein CD1A1 antigen, Beta-2-microglobulin, UNKNOWN LIGAND, ... (6 entities in total)
• 機能のキーワード: cd1, t-cell, lipid, antigen, transmembrane, disulfide bond, immune response, immunoglobulin domain, mhc i, polymorphism, secreted, immune system
• 由来する生物種: Gallus gallus (bantam,chickens); 詳細
• 細胞内の位置: Secreted: P21611
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 86686.94

構造登録者

Dvir, H.,Wang, J.,Zajonc, D.M. (登録日: 2009-09-16, 公開日: 2010-02-09, 最終更新日: 2024-10-30)

主引用文献

Dvir, H.,Wang, J.,Ly, N.,Dascher, C.C.,Zajonc, D.M.
Structural basis for lipid-antigen recognition in avian immunity.
J.Immunol., 184:2504-2511, 2010

PubMed Abstract: CD1 proteins present self- and foreign lipid Ags to activate specific T cells in the mammalian immune system. These T cells play an important role in controlling autoimmune diseases, suppression of tumor growth, and host defense against invading pathogens. Humans use five CD1 isoforms, whereas only two exist in birds. Unlike mammals' CD1, the structure of chicken CD1-2 showed a primitive lipid-binding groove, suggesting that chicken may only recognize single-chain lipids. In contrast, the crystal structure of the second chicken CD1 isoform, chCD1-1, reported in this study at 2.2 A resolution, reveals an elaborated binding groove with a dual-pocket, dual-cleft architecture. The A' and F' deep pockets are separated from each other, but each is connected to a hydrophobic surface cleft, which may participate in lipid binding. The long endogenous ligand found inside the binding groove of chCD1-1, together with binding data on various glycolipids and mycolic acid, strongly suggest that the unique avian CD1 family could bind long dual- and possibly triacyl-chain lipids.

PubMed: 20100930
DOI: 10.4049/jimmunol.0903509

実験手法

X-RAY DIFFRACTION (2.2 Å)