3JVG
Crystal Structure of chicken CD1-1
Summary for 3JVG
| Entry DOI | 10.2210/pdb3jvg/pdb |
| Related | 1ONQ 1UQS 1ZT4 2FIK 3dbx |
| Descriptor | T-cell surface glycoprotein CD1A1 antigen, Beta-2-microglobulin, UNKNOWN LIGAND, ... (6 entities in total) |
| Functional Keywords | cd1, t-cell, lipid, antigen, transmembrane, disulfide bond, immune response, immunoglobulin domain, mhc i, polymorphism, secreted, immune system |
| Biological source | Gallus gallus (bantam,chickens) More |
| Cellular location | Secreted: P21611 |
| Total number of polymer chains | 4 |
| Total formula weight | 86686.94 |
| Authors | Dvir, H.,Wang, J.,Zajonc, D.M. (deposition date: 2009-09-16, release date: 2010-02-09, Last modification date: 2024-10-30) |
| Primary citation | Dvir, H.,Wang, J.,Ly, N.,Dascher, C.C.,Zajonc, D.M. Structural basis for lipid-antigen recognition in avian immunity. J.Immunol., 184:2504-2511, 2010 Cited by PubMed Abstract: CD1 proteins present self- and foreign lipid Ags to activate specific T cells in the mammalian immune system. These T cells play an important role in controlling autoimmune diseases, suppression of tumor growth, and host defense against invading pathogens. Humans use five CD1 isoforms, whereas only two exist in birds. Unlike mammals' CD1, the structure of chicken CD1-2 showed a primitive lipid-binding groove, suggesting that chicken may only recognize single-chain lipids. In contrast, the crystal structure of the second chicken CD1 isoform, chCD1-1, reported in this study at 2.2 A resolution, reveals an elaborated binding groove with a dual-pocket, dual-cleft architecture. The A' and F' deep pockets are separated from each other, but each is connected to a hydrophobic surface cleft, which may participate in lipid binding. The long endogenous ligand found inside the binding groove of chCD1-1, together with binding data on various glycolipids and mycolic acid, strongly suggest that the unique avian CD1 family could bind long dual- and possibly triacyl-chain lipids. PubMed: 20100930DOI: 10.4049/jimmunol.0903509 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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