3JTC

Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins

3JTC の概要

• エントリーDOI: 10.2210/pdb3jtc/pdb
• 分子名称: Endothelial protein C receptor, Vitamin K-dependent protein C, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: gla (gamma-carboxyglutamic acid) residues, phospholipid binding groove, ca ion binding, blood clotting, blood coagulation, disulfide bond, glycoprotein, membrane, receptor, transmembrane, cleavage on pair of basic residues, disease mutation, egf-like domain, gamma-carboxyglutamic acid, hydrolase, hydroxylation, protease, serine protease, thrombophilia, zymogen
• 由来する生物種: HOMO SAPIENS (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56105.27

構造登録者

Bajaj, S.P.,Vadivel, K.,Agah, S.,Cascio, D.,Krishnaswamy, S.,Esmon, C.,Padmanabhan, K. (登録日: 2009-09-11, 公開日: 2011-04-06, 最終更新日: 2020-07-29)

• 主引用文献: Vadivel, K.,Agah, S.,Messer, A.S.,Cascio, D.,Bajaj, M.S.,Krishnaswamy, S.,Esmon, C.T.,Padmanabhan, K.,Bajaj, S.P.; Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium.; J.Mol.Biol., 425:1961-1981, 2013; PubMed: 23454357; DOI: 10.1016/j.jmb.2013.02.017

実験手法

X-RAY DIFFRACTION (1.6 Å)