3JAF

Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state

Summary for 3JAF

• Entry DOI: 10.2210/pdb3jaf/pdb
• Related: 3JAD 3JAE
• EMDB information: 6344 6345 6346
• Descriptor: Glycine receptor subunit alphaZ1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside (3 entities in total)
• Functional Keywords: cys loop receptor, alpha-1 glycine receptor, glycine, ivermectin, signaling protein
• Biological source: Danio rerio (zebra fish)
• Total number of polymer chains: 5
• Total formula weight: 202615.16

Authors

Du, J.,Lu, W.,Wu, S.P.,Cheng, Y.F.,Gouaux, E. (deposition date: 2015-06-08, release date: 2015-09-09, Last modification date: 2020-07-29)

• Primary citation: Du, J.,Lu, W.,Wu, S.,Cheng, Y.,Gouaux, E.; Glycine receptor mechanism elucidated by electron cryo-microscopy.; Nature, 526:224-229, 2015; PubMed: 26344198; DOI: 10.1038/nature14853

Experimental method

ELECTRON MICROSCOPY (3.801 Å)