3JAF
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state
Summary for 3JAF
Entry DOI | 10.2210/pdb3jaf/pdb |
Related | 3JAD 3JAE |
EMDB information | 6344 6345 6346 |
Descriptor | Glycine receptor subunit alphaZ1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside (3 entities in total) |
Functional Keywords | cys loop receptor, alpha-1 glycine receptor, glycine, ivermectin, signaling protein |
Biological source | Danio rerio (zebra fish) |
Total number of polymer chains | 5 |
Total formula weight | 202615.16 |
Authors | Du, J.,Lu, W.,Wu, S.P.,Cheng, Y.F.,Gouaux, E. (deposition date: 2015-06-08, release date: 2015-09-09, Last modification date: 2020-07-29) |
Primary citation | Du, J.,Lu, W.,Wu, S.,Cheng, Y.,Gouaux, E. Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature, 526:224-229, 2015 Cited by PubMed: 26344198DOI: 10.1038/nature14853 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.801 Å) |
Structure validation
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