3IWU
Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase
Summary for 3IWU
| Entry DOI | 10.2210/pdb3iwu/pdb |
| Related | 2H1X 2H6U 3IWV |
| Descriptor | 5-hydroxyisourate hydrolase (2 entities in total) |
| Functional Keywords | hiuase, transthyretin, trp, thyroid hormones, molecular evolution, hydrolase, peroxisome, purine metabolism |
| Biological source | Danio rerio (Zebrafish) |
| Total number of polymer chains | 8 |
| Total formula weight | 123196.59 |
| Authors | Cendron, L.,Ramazzina, I.,Berni, R.,Percudani, R.,Zanotti, G. (deposition date: 2009-09-03, release date: 2010-09-01, Last modification date: 2023-11-01) |
| Primary citation | Cendron, L.,Ramazzina, I.,Percudani, R.,Rasore, C.,Zanotti, G.,Berni, R. Probing the evolution of hydroxyisourate hydrolase into transthyretin through active-site redesign. J.Mol.Biol., 409:504-512, 2011 Cited by PubMed: 21515285DOI: 10.1016/j.jmb.2011.04.022 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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