3IWU

Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005777	cellular_component	peroxisome
A	0006144	biological_process	purine nucleobase metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0019628	biological_process	urate catabolic process
A	0033971	molecular_function	hydroxyisourate hydrolase activity
B	0005777	cellular_component	peroxisome
B	0006144	biological_process	purine nucleobase metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0019628	biological_process	urate catabolic process
B	0033971	molecular_function	hydroxyisourate hydrolase activity
C	0005777	cellular_component	peroxisome
C	0006144	biological_process	purine nucleobase metabolic process
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0019628	biological_process	urate catabolic process
C	0033971	molecular_function	hydroxyisourate hydrolase activity
D	0005777	cellular_component	peroxisome
D	0006144	biological_process	purine nucleobase metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
D	0019628	biological_process	urate catabolic process
D	0033971	molecular_function	hydroxyisourate hydrolase activity
E	0005777	cellular_component	peroxisome
E	0006144	biological_process	purine nucleobase metabolic process
E	0016787	molecular_function	hydrolase activity
E	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
E	0019628	biological_process	urate catabolic process
E	0033971	molecular_function	hydroxyisourate hydrolase activity
F	0005777	cellular_component	peroxisome
F	0006144	biological_process	purine nucleobase metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
F	0019628	biological_process	urate catabolic process
F	0033971	molecular_function	hydroxyisourate hydrolase activity
G	0005777	cellular_component	peroxisome
G	0006144	biological_process	purine nucleobase metabolic process
G	0016787	molecular_function	hydrolase activity
G	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
G	0019628	biological_process	urate catabolic process
G	0033971	molecular_function	hydroxyisourate hydrolase activity
H	0005777	cellular_component	peroxisome
H	0006144	biological_process	purine nucleobase metabolic process
H	0016787	molecular_function	hydrolase activity
H	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
H	0019628	biological_process	urate catabolic process
H	0033971	molecular_function	hydroxyisourate hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. HVLNaaqGvPGanMtI

Chain	Residue	Details
A	HIS12-ILE27

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS12
D	HIS12
D	ARG52
D	THR116
E	HIS12
E	ARG52
E	THR116
F	HIS12
F	ARG52
F	THR116
G	HIS12
A	ARG52
G	ARG52
G	THR116
H	HIS12
H	ARG52
H	THR116
A	THR116
B	HIS12
B	ARG52
B	THR116
C	HIS12
C	ARG52
C	THR116

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