3IU3

Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain

Summary for 3IU3

• Entry DOI: 10.2210/pdb3iu3/pdb
• Descriptor: Heavy chain of Fab fragment of Basiliximab, Light chain of Fab fragment of Basiliximab, Interleukin-2 receptor alpha chain, ... (4 entities in total)
• Functional Keywords: il-2ra, cd25, basiliximab, simulect, therapeutic antibody, disulfide bond, glycoprotein, membrane, receptor, sushi, transmembrane, immune system
• Biological source: Mus musculus, Homo sapiens (mouse, human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01589
• Total number of polymer chains: 9
• Total formula weight: 216006.16

Authors

Du, J.,Yang, H.,Wang, J.,Ding, J. (deposition date: 2009-08-29, release date: 2010-01-26, Last modification date: 2023-11-01)

• Primary citation: Du, J.,Yang, H.,Zhang, D.,Wang, J.,Guo, H.,Peng, B.,Guo, Y.,Ding, J.; Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab; J.Immunol., 184:1361-1368, 2010; PubMed: 20032294; DOI: 10.4049/jimmunol.0903178

Experimental method

X-RAY DIFFRACTION (2.9 Å)