3IU3

Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, H)	Heavy chain of Fab fragment of Basiliximab	polymer	215	23144.8	3		Mus musculus Homo sapiens (mouse human)
2	B, D, F (B, D, L)	Light chain of Fab fragment of Basiliximab	polymer	210	22882.3	3	Pfam (PF07654) UniProt (by SIFTS) (P01834)	Mus musculus Homo sapiens (mouse human)
3	G, H, I (I, J, K)	Interleukin-2 receptor alpha chain	polymer	223	25388.3	3	UniProt (P01589) Pfam (PF00084)	Homo sapiens (human)	IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen
4	J, K, L (E, F, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)

Sequence modifications

I, J, K: 1 - 217 (UniProt: P01589)

PDB	External Database	Details
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	214246.5
Branched	Number of molecules	3
	Total formula weight	1759.6
All*	Total formula weight	216006.2

*Water molecules are not included.