3IU3

Crystal structure of the Fab fragment of therapeutic antibody Basiliximab in complex with IL-2Ra (CD25) ectodomain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0003823	molecular_function	antigen binding
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0016064	biological_process	immunoglobulin mediated immune response
B	0050853	biological_process	B cell receptor signaling pathway
B	0070062	cellular_component	extracellular exosome
B	0071735	cellular_component	IgG immunoglobulin complex
B	0071738	cellular_component	IgD immunoglobulin complex
B	0071742	cellular_component	IgE immunoglobulin complex
B	0071745	cellular_component	IgA immunoglobulin complex
B	0071753	cellular_component	IgM immunoglobulin complex
B	0072562	cellular_component	blood microparticle
D	0002250	biological_process	adaptive immune response
D	0003823	molecular_function	antigen binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0016064	biological_process	immunoglobulin mediated immune response
D	0050853	biological_process	B cell receptor signaling pathway
D	0070062	cellular_component	extracellular exosome
D	0071735	cellular_component	IgG immunoglobulin complex
D	0071738	cellular_component	IgD immunoglobulin complex
D	0071742	cellular_component	IgE immunoglobulin complex
D	0071745	cellular_component	IgA immunoglobulin complex
D	0071753	cellular_component	IgM immunoglobulin complex
D	0072562	cellular_component	blood microparticle
I	0004911	molecular_function	interleukin-2 receptor activity
I	0019976	molecular_function	interleukin-2 binding
J	0004911	molecular_function	interleukin-2 receptor activity
J	0019976	molecular_function	interleukin-2 binding
K	0004911	molecular_function	interleukin-2 receptor activity
K	0019976	molecular_function	interleukin-2 binding
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
B	TYR189-HIS195
A	TYR196-HIS202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	291
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3134887","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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