3ISW

Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR

3ISW の概要

• エントリーDOI: 10.2210/pdb3isw/pdb
• 分子名称: Filamin-A, Cystic fibrosis transmembrane conductance regulator (3 entities in total)
• 機能のキーワード: protein-peptide complex, acetylation, actin-binding, alternative splicing, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, polymorphism, atp-binding, chloride, chloride channel, glycoprotein, hydrolase, ion transport, ionic channel, membrane, nucleotide-binding, transmembrane, transport, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cell cortex: P21333; Early endosome membrane; Multi-pass membrane protein: P13569
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22363.74

構造登録者

Xu, Z.,Page, R.,Qin, J.,Ithychanda, S.S.,Liu, J.M.,Misra, S. (登録日: 2009-08-27, 公開日: 2010-04-07, 最終更新日: 2023-09-06)

• 主引用文献: Smith, L.,Page, R.C.,Xu, Z.,Kohli, E.,Litman, P.,Nix, J.C.,Ithychanda, S.S.,Liu, J.,Qin, J.,Misra, S.,Liedtke, C.M.; Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.; J.Biol.Chem., 285:17166-17176, 2010; PubMed: 20351101; DOI: 10.1074/jbc.M109.080911

実験手法

X-RAY DIFFRACTION (2.8 Å)