3IOB

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.80 Ang resolution in complex with 5'-deoxy-5'-thioadenosine

Summary for 3IOB

• Entry DOI: 10.2210/pdb3iob/pdb
• Related: 1N2H 3COV 3COW 3COY 3COZ 3IOC 3IOD 3IOE
• Descriptor: Pantothenate synthetase, 5'-thioadenosine, SULFATE ION, ... (6 entities in total)
• Functional Keywords: mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, fragment-based, dynamic combinatorial chemistry, atp-binding, magnesium, metal-binding, nucleotide-binding
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 64361.61

Authors

Ciulli, A.,Scott, D.E.,Abell, C. (deposition date: 2009-08-14, release date: 2009-12-01, Last modification date: 2023-09-06)

• Primary citation: Scott, D.E.,Dawes, G.J.,Ando, M.,Abell, C.,Ciulli, A.; A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry; Chembiochem, 10:2772-2779, 2009; PubMed: 19827080; DOI: 10.1002/cbic.200900537

Experimental method

X-RAY DIFFRACTION (1.8 Å)