3IOC

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.50 Ang resolution in complex with 5'-deoxy-5'-(benzyldisulfanyl)-adenosine

Summary for 3IOC

Entry DOI	10.2210/pdb3ioc/pdb
Related	1N2H 3COV 3COW 3COY 3COZ 3IOB 3IOD 3IOE
Descriptor	Pantothenate synthetase, GLYCEROL, (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(benzyldisulfanyl)methyl]tetrahydrofuran-3,4-diol, ... (4 entities in total)
Functional Keywords	mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, fragment-based, dynamic combinatorial chemistry, atp-binding, magnesium, metal-binding, nucleotide-binding
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	64137.53
Authors	Ciulli, A.,Scott, D.E.,Abell, C. (deposition date: 2009-08-14, release date: 2009-12-01, Last modification date: 2023-09-06)
Primary citation	Scott, D.E.,Dawes, G.J.,Ando, M.,Abell, C.,Ciulli, A. A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry Chembiochem, 10:2772-2779, 2009 Cited by PubMed: 19827080 DOI: 10.1002/cbic.200900537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation