3IOC
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.50 Ang resolution in complex with 5'-deoxy-5'-(benzyldisulfanyl)-adenosine
Summary for 3IOC
Entry DOI | 10.2210/pdb3ioc/pdb |
Related | 1N2H 3COV 3COW 3COY 3COZ 3IOB 3IOD 3IOE |
Descriptor | Pantothenate synthetase, GLYCEROL, (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(benzyldisulfanyl)methyl]tetrahydrofuran-3,4-diol, ... (4 entities in total) |
Functional Keywords | mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, fragment-based, dynamic combinatorial chemistry, atp-binding, magnesium, metal-binding, nucleotide-binding |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 64137.53 |
Authors | Ciulli, A.,Scott, D.E.,Abell, C. (deposition date: 2009-08-14, release date: 2009-12-01, Last modification date: 2023-09-06) |
Primary citation | Scott, D.E.,Dawes, G.J.,Ando, M.,Abell, C.,Ciulli, A. A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry Chembiochem, 10:2772-2779, 2009 Cited by PubMed: 19827080DOI: 10.1002/cbic.200900537 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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