3IKM
Crystal structure of human mitochondrial DNA polymerase holoenzyme
Summary for 3IKM
Entry DOI | 10.2210/pdb3ikm/pdb |
Descriptor | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2 (2 entities in total) |
Functional Keywords | human mitochondrial dna polymerase, disease mutation, dna replication, dna-binding, dna-directed dna polymerase, magnesium, mitochondrion, neuropathy, nucleotidyltransferase, progressive external ophthalmoplegia, transferase, transit peptide |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion : P54098 Q9UHN1 |
Total number of polymer chains | 6 |
Total formula weight | 459800.98 |
Authors | Lee, Y.-S.,Kennedy, W.D.,Yin, Y.W. (deposition date: 2009-08-06, release date: 2009-11-03, Last modification date: 2024-02-21) |
Primary citation | Lee, Y.S.,Kennedy, W.D.,Yin, Y.W. Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell(Cambridge,Mass.), 139:312-324, 2009 Cited by PubMed: 19837034DOI: 10.1016/j.cell.2009.07.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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