3IKM
Crystal structure of human mitochondrial DNA polymerase holoenzyme
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005760 | cellular_component | gamma DNA polymerase complex |
| A | 0006260 | biological_process | DNA replication |
| A | 0006264 | biological_process | mitochondrial DNA replication |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| D | 0005760 | cellular_component | gamma DNA polymerase complex |
| D | 0006260 | biological_process | DNA replication |
| D | 0006264 | biological_process | mitochondrial DNA replication |
Functional Information from PROSITE/UniProt
| site_id | PS00447 |
| Number of Residues | 20 |
| Details | DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA |
| Chain | Residue | Details |
| A | ARG943-ALA962 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 122 |
| Details | Region: {"description":"Accessory-interacting determinant","evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Region: {"description":"Trigger loop","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Exo I","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Exo II","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Exo III","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Motif: {"description":"Pol A","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 30 |
| Details | Motif: {"description":"Pol B","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 14 |
| Details | Motif: {"description":"Pol C","evidences":[{"source":"PubMed","id":"15189144","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"8884268","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Exonuclease activity","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8D37","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26056153","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZTZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | Site: {"description":"Critical for replication fidelity and mismatch recognition","evidences":[{"source":"PubMed","id":"37202477","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| B | HIS216 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| C | HIS216 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| E | HIS216 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| F | HIS216 |
