3IKM

Crystal structure of human mitochondrial DNA polymerase holoenzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005760	cellular_component	gamma DNA polymerase complex
A	0006260	biological_process	DNA replication
A	0006264	biological_process	mitochondrial DNA replication
D	0003677	molecular_function	DNA binding
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005760	cellular_component	gamma DNA polymerase complex
D	0006260	biological_process	DNA replication
D	0006264	biological_process	mitochondrial DNA replication

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RehAKifnYGriYgaGqpfA

Chain	Residue	Details
A	ARG943-ALA962

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Exonuclease activity => ECO:0000269|PubMed:37202477

Chain	Residue	Details
A	ASP198
D	ASP198

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:37202477, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	SER306
D	SER1095
A	LYS806
A	SER893
A	ARG943
A	SER1095
D	SER306
D	LYS806
D	SER893
D	ARG943

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:26056153, ECO:0007744|PDB:4ZTZ

Chain	Residue	Details
A	ARG579
A	ARG869
D	ARG579
D	ARG869

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0000269|PubMed:37202477, ECO:0007744|PDB:4ZTZ, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	SER593
A	LYS947
A	TYR951
D	SER593
D	LYS947
D	TYR951

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site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:37202477, ECO:0007744|PDB:8D37

Chain	Residue	Details
A	HIS754
A	GLY763
A	LYS768
A	SER863
D	HIS754
D	GLY763
D	LYS768
D	SER863

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site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:26056153, ECO:0007744|PDB:4ZTZ

Chain	Residue	Details
A	THR849
D	GLU895
D	THR1094
D	ASP1135
A	ASP890
A	VAL891
A	GLU895
A	THR1094
A	ASP1135
D	THR849
D	ASP890
D	VAL891

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site_id	SWS_FT_FI7
Number of Residues	4
Details	SITE: Critical for replication fidelity and mismatch recognition => ECO:0000269|PubMed:37202477

Chain	Residue	Details
A	ARG853
A	GLN1102
D	ARG853
D	GLN1102

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
B	HIS216

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
C	HIS216

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
E	HIS216

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1qf6

Chain	Residue	Details
F	HIS216

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