3IK1

Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C

3IK1 の概要

• エントリーDOI: 10.2210/pdb3ik1/pdb
• 関連するPDBエントリー: 3BNZ 3BYX 3BZ0 3C06 3C0A 3IJZ 3IK0
• 分子名称: Thymidylate synthase, 2-hydroxy-4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: transferase, nucleotide synthase, methyltransferase, nucleotide biosynthesis
• 由来する生物種: Lactobacillus casei
• 細胞内の位置: Cytoplasm: P00469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37235.90

構造登録者

Pozzi, C.,Cancian, L.,Leone, R.,Luciani, R.,Ferrari, S.,Mangani, S.,Costi, M.P. (登録日: 2009-08-05, 公開日: 2010-08-11, 最終更新日: 2023-11-01)

• 主引用文献: Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P.; Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening; J.Med.Chem., 54:5454-5467, 2011; PubMed: 21696158; DOI: 10.1021/jm2005018

実験手法

X-RAY DIFFRACTION (2.25 Å)