3IK0
Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 7C1
Summary for 3IK0
Entry DOI | 10.2210/pdb3ik0/pdb |
Related | 3BYX 3BZ0 3BZN 3C06 3C0A 3IJZ 3IK1 |
Descriptor | Thymidylate synthase, 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenecarboximidamide, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total) |
Functional Keywords | transferase, nucleotide synthase, methyltransferase, nucleotide biosynthesis |
Biological source | Lactobacillus casei |
Cellular location | Cytoplasm: P00469 |
Total number of polymer chains | 1 |
Total formula weight | 37217.93 |
Authors | Pozzi, C.,Cancian, L.,Leone, R.,Luciani, R.,Ferrari, S.,Mangani, S.,Costi, M.P. (deposition date: 2009-08-05, release date: 2010-08-11, Last modification date: 2023-11-01) |
Primary citation | Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158DOI: 10.1021/jm2005018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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