3BNZ

Crystal structure of Thymidylate Synthase ternary complex with dUMP and 8A inhibitor

Summary for 3BNZ

Entry DOI	10.2210/pdb3bnz/pdb
Related	1LCA
Descriptor	Thymidylate synthase, PHOSPHATE ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	thymidylate synthase, methyltransferase, nucleotide biosynthesis, transferase
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	37295.87
Authors	Leone, R.,Cancian, L.,Luciani, R.,Ferrari, S.,Costi, M.P.,Mangani, S. (deposition date: 2007-12-15, release date: 2008-12-16, Last modification date: 2023-11-01)
Primary citation	Mangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54:5454-5467, 2011 Cited by PubMed: 21696158 DOI: 10.1021/jm2005018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation